Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 2/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20873850 | 0.84 | CHRM5 (0.48) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| SCHEMBL731212 | 0.84 | CHRM5 (0.48) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| SCHEMBL2912326 | 0.84 | CHRM5 (0.48) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| SCHEMBL92626 | 0.84 | CHRM5 (0.48) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| Hydrochloric Acid SCHEMBL4668199 | 0.82 | CHRM5 (0.46) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| SCHEMBL2570307 | 0.82 | GBA1 (0.47) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| Hydrochloric Acid SCHEMBL5570644 | 0.82 | CHRM5 (0.46) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| Hydrochloric Acid SCHEMBL21001940 | 0.82 | CHRM5 (0.46) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| Bromide SCHEMBL31114948 | 0.82 | CHRM5 (0.46) | CHRM5ADRA2CCNR1ACHEGBA1 | |
| SCHEMBL2249609 | 0.80 | CHRM5 (0.62) | CHRM5ADRA2CACHESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |