Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078318 | 0.76 | LMNA (0.46) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL28815192 | 0.74 | LMNA (0.44) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| Water SCHEMBL26669930 | 0.74 | LMNA (0.44) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL25530903 | 0.74 | LMNA (0.40) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL5017464 | 0.74 | LMNA (0.40) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL10347592 | 0.74 | LMNA (0.44) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL284393 | 0.74 | LMNA (0.40) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL5015978 | 0.74 | LMNA (0.40) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL1117295 | 0.74 | LMNA (0.44) | LMNAOPRM1OPRD1SLC6A2SLC6A4 | |
| SCHEMBL10078986 | 0.72 | LMNA (0.42) | LMNAOPRM1OPRD1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215085-B1 | PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-09-07 | — | — | EP | disclosed |