Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TACR2 | P21452 | 3/20 | 0.42 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.42 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.42 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | GJB2 | P29033 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.41 |
| ▸ | CDC25B | P30305 | 5/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19189222 | 0.86 | HTR1A (0.51) | HTR1ANT5EBCHEACHETACR2 | |
| SCHEMBL19189070 | 0.86 | HTR1A (0.51) | HTR1ANT5EBCHEACHETACR2 | |
| SCHEMBL9850224 | 0.84 | NT5E (0.49) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL21418869 | 0.83 | PDE2A (0.50) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL16756817 | 0.83 | PDE2A (0.48) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL23989131 | 0.83 | PDE2A (0.50) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL19227794 | 0.83 | PDE2A (0.48) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL24371602 | 0.83 | PDE2A (0.48) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL16756820 | 0.83 | PDE2A (0.48) | PDE2AHTR1ANT5EBCHEACHE | |
| SCHEMBL18636425 | 0.83 | PDE2A (0.48) | PDE2AHTR1ANT5EBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365970-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | ALIGOS THERAPEUTICS, INC. (US) | 2023-11-16 | — | — | US | disclosed |
| US-20230332153-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | ALIGOS THERAPEUTICS, INC. (US) | 2023-10-19 | — | — | US | disclosed |
| US-11549110-B2 | Modified short interfering nucleic acid (siNA) molecules and uses thereof | ALIGOS THERAPEUTICS, INC. (US) | 2023-01-10 | — | — | US | disclosed |
| US-20220177888-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | ALIGOS THERAPEUTICS, INC. (US) | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365970-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | NSUN2, SNRPA, SNRPF | PDE2A 1748/4885HTR1A 3301/4885NT5E 195/4885 |
| US-11549110-B2 | Modified short interfering nucleic acid (siNA) molecules and uses thereof | NSUN2, SNRPA, SNRPF | PDE2A 1748/4885HTR1A 3301/4885NT5E 195/4885 |
| US-20220177888-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | NSUN2, SNRPA, SNRPF | PDE2A 1748/4885HTR1A 3301/4885NT5E 195/4885 |
| US-20230332153-A1 | Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof | NSUN2, SNRPA, SNRPF | PDE2A 1748/4885HTR1A 3301/4885NT5E 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.