⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247969 | 1.00 | — | — | |
| SCHEMBL5626593 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4667642 | 0.98 | ALDH1A1 (0.48) | — | |
| Hydrochloric Acid SCHEMBL4667641 | 0.98 | ALDH1A1 (0.48) | — | |
| SCHEMBL11060437 | 0.94 | HPGD (0.45) | — | |
| SCHEMBL26161652 | 0.89 | — | — | |
| SCHEMBL14690619 | 0.89 | — | — | |
| SCHEMBL611743 | 0.86 | KMT2A (0.53) | — | |
| SCHEMBL13102163 | 0.83 | KMT2A (0.45) | — | |
| SCHEMBL2239461 | 0.83 | KMT2A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188101-B2 | Dihydropyridopyrimidines for the treatment of AB-related pathologies | ASTRAZENECA AB (SE) | 2012-05-29 | — | — | US | claimed |
| EP-2367826-A1 | MODULATORS OF AMYLOID BETA. | AstraZeneca AB (SE) | 2011-09-28 | — | — | EP | claimed |
| US-20100130495-A1 | COMPOUNDS 563 | ASTRAZENECA AB (SE) | 2010-05-27 | — | — | US | claimed |
| WO-2010053438-A1 | MODULATORS OF AMYLOID BETA. | ASTRAZENECA AB (SE) | 2010-05-14 | — | — | WO | claimed |
| US-11352340-B2 | Pyridine and pyridimine compounds as PI3K-gamma inhibitors | INCYTE CORPORATION (US) | 2022-06-07 | — | — | US | disclosed |
| EP-2986604-B1 | PYRIMIDINE-SUBSTITUTED PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2017-12-20 | — | — | EP | disclosed |
| US-9782407-B2 | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2017-10-10 | — | — | US | disclosed |
| US-9765030-B2 | Benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors | DR. REDDY'S LABORATORIES LTD. (IN) | 2017-09-19 | — | — | US | disclosed |
| EP-1848430-B1 | NOVEL BENZYLAMINE DERIVATIVES AS CETP INHIBITORS | Dr Reddys Laboratories Ltd (IN) | 2017-08-02 | — | — | EP | disclosed |
| WO-2017120194-A1 | PYRIDINE AND PYRIDIMINE COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2017-07-13 | — | — | WO | disclosed |
| CN-106432059-A | Preparation method of 3-hydroxypiperidine, preparation method of derivative of 3-hydroxypiperidine, and intermediate of 3-hydroxypiperidine | 上海朴颐化学科技有限公司 | 2017-02-22 | — | — | CN | disclosed |
| US-20160368908-A1 | BENZIMIDAZOLE DERIVATIVES AS RLK AND ITK INHIBITORS | PRINCIPIA BIOPHARMA, INC. | 2016-12-22 | — | — | US | disclosed |
| EP-0262810-B1 | SHEET RECORDING MATERIAL CONTAINING DYE-FORMING COMPONENTS | Fuji Photo Film Co., Ltd. (JP) | 1992-12-09 | — | — | EP | disclosed |
| US-5166350-A | Process for the manufacture of fluoran compounds | CIBA-GEIGY CORPORATION (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0433805-A1 | N-Substituted 3-cyano-4-phenyl-pyrroles | BAYER AG (DE) | 1991-06-26 | — | — | EP | disclosed |
| EP-0424525-A1 | NOVEL AMINES AND THEIR USE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1991-05-02 | — | — | EP | disclosed |
| US-4973712-A | 2-aralkylaminofluorans, their preparation and the use thereof in recording materials | CIBA-GEIGY CORPORATION (US) | 1990-11-27 | — | — | US | disclosed |
| US-4808566-A | COLORLESS DYE IS DIMER OF 3-(4-SUBSTITUTED AMINOARYL)-3-(SUBSTITUTED INDOL-3-YL) PHTHALIDE | FUJI PHOTO FILM CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |
| EP-0275203-A2 | Heat-sensitive recording material containing color forming components | FUJI PHOTO FILM CO., LTD. (JP) | 1988-07-20 | — | — | EP | disclosed |
| US-4404018-A | Furfuryl amides of phenoxyphenoxyalkanoic acids and herbicidal use | VELSICOL CHEMICAL CORPORATION (US) | 1983-09-13 | — | — | US | disclosed |