Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 19/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30045226 | 0.91 | TTK (0.35) | PTPN11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21240454 | 0.91 | TTK (0.35) | PTPN11PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL21240142 | 0.91 | PDE10A (0.35) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29577848 | 0.91 | PDE10A (0.35) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL21240537 | 0.88 | NOS1 (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL20331789 | 0.88 | NOS1 (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29578158 | 0.88 | NOS1 (0.36) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL30045100 | 0.88 | NOS1 (0.38) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL21240135 | 0.88 | PDE9A (0.34) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29577336 | 0.88 | PDE9A (0.34) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |