Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 13/20 | 0.48 |
| ▸ | ATP4B | P51164 | 13/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2379350 | 0.99 | ATP4A (0.49) | ATP4AATP4BCYP19A1NPC1MAPT | |
| SCHEMBL2381362 | 0.94 | ATP4A (0.45) | ATP4AATP4BCYP19A1NPC1MAPT | |
| SCHEMBL2378921 | 0.93 | ATP4A (0.44) | ATP4AATP4BCYP19A1NPC1MAPT | |
| SCHEMBL2379678 | 0.90 | ATP4A (0.49) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2380476 | 0.88 | ATP4A (0.51) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2379700 | 0.87 | ATP4A (0.48) | ATP4AATP4BNPC1MAPTRAB9A | |
| SCHEMBL2449269 | 0.86 | ATP4A (0.67) | ATP4AATP4BCYP19A1NPC1MAPT | |
| SCHEMBL2380595 | 0.86 | ATP4A (0.53) | ATP4AATP4BNPC1MAPTRAB9A | |
| Bromide SCHEMBL2379078 | 0.85 | ATP4A (0.68) | ATP4AATP4BCYP19A1NPC1MAPT | |
| SCHEMBL2379117 | 0.84 | ATP4A (0.61) | ATP4AATP4BNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716127-B1 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBVIE DEUTSCHLAND (DE) | 2014-08-06 | — | — | EP | disclosed |
| EP-2380885-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366697-A1 | Guanidine compounds and use of same as binding partners for 5-HT5 receptors | Abbott GmbH & Co. KG (DE) | 2011-09-21 | — | — | EP | disclosed |
| EP-1716127-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | Abbott GmbH & Co. KG (DE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005082871-A2 | GUANIDINE COMPOUNDS, AND USE THEREOF AS BINDING PARTNERS FOR 5-HT5 RECEPTORS | ABBOTT GMBH & CO. KG (DE) | 2005-09-09 | — | — | WO | disclosed |