Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.34 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | NEK2 | P51955 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252225 | 0.90 | NOS1 (0.45) | NOS1MAP2K7GAKMAP4K1 | |
| SCHEMBL21251916 | 0.89 | TTK (0.39) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL21252039 | 0.88 | TTK (0.37) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL21602818 | 0.88 | NOS1 (0.38) | NOS1LRRK2GAKMAP4K1 | |
| SCHEMBL24488400 | 0.87 | MAP3K12 (0.38) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL24488321 | 0.87 | NOS1 (0.44) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL20330834 | 0.86 | TTK (0.37) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL21251781 | 0.85 | JAK2 (0.36) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL21252086 | 0.85 | JAK2 (0.38) | NOS1JAK2JAK1TYK2KDR | |
| SCHEMBL21252314 | 0.85 | GAK (0.39) | JAK2JAK1TYK2KDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |