Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 20/20 | 0.75 |
| ▸ | DDX5 | P17844 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593859 | 0.88 | TOP1 (0.75) | TOP1DDX5 | |
| SCHEMBL21593871 | 0.88 | TOP1 (0.75) | TOP1 | |
| SCHEMBL21593868 | 0.86 | TOP1 (0.72) | TOP1 | |
| SCHEMBL21450564 | 0.86 | TOP1 (1.00) | TOP1DDX5 | |
| SCHEMBL21450567 | 0.85 | TOP1 (1.00) | TOP1DDX5 | |
| SCHEMBL21450569 | 0.85 | TOP1 (0.95) | TOP1DDX5 | |
| SCHEMBL21591950 | 0.84 | TOP1 (0.74) | TOP1DDX5 | |
| SCHEMBL24490150 | 0.84 | TOP1 (0.63) | TOP1 | |
| SCHEMBL21593898 | 0.84 | TOP1 (0.81) | TOP1DDX5 | |
| SCHEMBL23255624 | 0.84 | TOP1 (0.73) | TOP1DDX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177485-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD. (CN) | 2022-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177485-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | WEE1, WASF2, WEE2 | TOP1 10/4885DDX5 2607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.