Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 18/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | FGR | P09769 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178822 | 0.77 | RET (0.52) | RET | |
| SCHEMBL21178845 | 0.76 | RET (0.75) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21178853 | 0.74 | RET (0.76) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21178907 | 0.74 | RET (0.76) | RETSRC | |
| SCHEMBL31639888 | 0.74 | RET (0.76) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21801382 | 0.72 | RET (0.50) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL19366587 | 0.71 | SRC (0.40) | SRC | |
| SCHEMBL21801375 | 0.69 | RET (0.52) | RETCYP1A2HCKFGRRPS6KB1 | |
| SCHEMBL21178912 | 0.68 | RET (1.00) | RETKDRSRC | |
| SCHEMBL21178840 | 0.68 | RET (1.00) | RETCYP1A2HCKFGRRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3849986-B1 | FUSED HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2022-06-08 | — | — | EP | disclosed |