Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ADK | P55263 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19366442 | 0.84 | ADK (0.33) | ADK | |
| SCHEMBL13616238 | 0.81 | ALDH1A1 (0.38) | SRCADKALDH1A1MAPT | |
| SCHEMBL18967243 | 0.74 | ADK (0.39) | SRCADKMEN1NR2F2KMT2A | |
| SCHEMBL21170650 | 0.73 | PDE4A (0.38) | SRCMEN1NR2F2KMT2AALDH1A1 | |
| SCHEMBL25065735 | 0.73 | SRC (0.67) | SRCADKMEN1NR2F2KMT2A | |
| SCHEMBL398024 | 0.73 | SRC (0.67) | SRCADKMEN1NR2F2KMT2A | |
| SCHEMBL18902127 | 0.72 | JAK2 (0.35) | ALDH1A1HTT | |
| SCHEMBL24490651 | 0.71 | RET (0.52) | SRC | |
| SCHEMBL18380981 | 0.70 | PDE4A (0.35) | SRCMEN1NR2F2KMT2AALDH1A1 | |
| SCHEMBL3232814 | 0.69 | SRC (0.42) | SRCADKMEN1NR2F2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560972-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2017-09-20 | — | — | EP | disclosed |