Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL480656 | 0.78 | KDM4E (0.53) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL17941788 | 0.77 | PDE1A (0.43) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL19374980 | 0.76 | KDM4E (0.56) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL480856 | 0.73 | KDM4E (0.49) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL2445185 | 0.73 | KDM4E (0.49) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL9388600 | 0.72 | KDM4E (0.47) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL18120283 | 0.71 | KDM4E (0.46) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL24451139 | 0.70 | MAPT (0.72) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL6460417 | 0.69 | PKM (0.51) | KDM4EMEN1KMT2AMAPTLMNA | |
| SCHEMBL31085048 | 0.69 | PKM (0.41) | KDM4EMAPTLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109734716-B | Doxofylline impurity and preparation method thereof | 四川蓝励医药科技有限公司 | 2021-10-26 | — | — | CN | disclosed |
| WO-2016159746-A1 | NOVEL ETHYNYLXANTHINES, THEIR PREPARATION AND USE AS INHIBITORS OF MATRIX METALLOPROTEINASES AND ANGIOGENESIS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016159746-A1 | NOVEL ETHYNYLXANTHINES, THEIR PREPARATION AND USE AS INHIBITORS OF MATRIX METALLOPROTEINASES AND ANGIOGENESIS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016159747-A1 | ETHYNYLXANTHINES, PREPARATION AND USE AS CALCIUM ION CHANNEL MODULATORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016159747-A1 | ETHYNYLXANTHINES, PREPARATION AND USE AS CALCIUM ION CHANNEL MODULATORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016159745-A1 | ETHYNYLXANTHINES, PREPARATION AND USE FOR CANCER TREATMENT | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016159745-A1 | ETHYNYLXANTHINES, PREPARATION AND USE FOR CANCER TREATMENT | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-10-06 | — | — | WO | disclosed |
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |
| US-5786361-A | ANTIATHEROSCLEROSIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-07-28 | — | — | US | disclosed |
| EP-0802198-A2 | Pyridazino-, pyrimido, pyrazino and triazino-indoles | BAYER AG (DE) | 1997-10-22 | — | — | EP | disclosed |
| EP-0369627-B1 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-12-21 | — | — | EP | disclosed |
| US-5008267-A | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1991-04-16 | — | — | US | disclosed |
| EP-0369627-A2 | Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-05-23 | — | — | EP | disclosed |
| EP-0125523-B1 | SILVER HALIDE PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-01 | — | — | EP | disclosed |
| US-4737442-A | INCLUDING A SENSITIZER AND A BLOCKED DEVELOPMENT RESTRAINER; FREE OF BLACK SPOTS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| US-4518685-A | BLOCKED AGENT FOR STORAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1985-05-21 | — | — | US | disclosed |
| EP-0125523-A2 | Silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 1984-11-21 | — | — | EP | disclosed |
| EP-0037495-A1 | Pyrimidyl quinazolines, process for their preparation and pharmaceutical compositions containing them | CASSELLA Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |
| US-4067982-A | LOWERING BLOOD PRESSURE, ANALGESIC, SEDATIVE, ANTIHISTAMINE | Gulden, Byk (DT) | 1978-01-10 | — | — | US | disclosed |
| US-3957786-A | HYPOTENSIVE AGENTS | BYK GULDEN (DT) | 1976-05-18 | — | — | US | disclosed |