Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 2/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 6/20 | 0.37 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648428 | 1.00 | BMP1 (0.39) | BMP1KAT8TEAD1YAP1MEN1 | |
| SCHEMBL24495998 | 0.93 | TEAD1 (0.37) | BMP1KAT8TEAD1YAP1MEN1 | |
| SCHEMBL29648378 | 0.93 | TEAD1 (0.37) | BMP1KAT8TEAD1YAP1MEN1 | |
| SCHEMBL24496182 | 0.90 | TEAD1 (0.39) | KAT8TEAD1YAP1MEN1KMT2A | |
| SCHEMBL29648333 | 0.90 | TEAD1 (0.39) | KAT8TEAD1YAP1MEN1KMT2A | |
| SCHEMBL24495997 | 0.89 | TSHR (0.38) | KAT8TEAD1YAP1MEN1KMT2A | |
| SCHEMBL29648312 | 0.89 | TSHR (0.38) | KAT8TEAD1YAP1MEN1KMT2A | |
| SCHEMBL22718097 | 0.87 | TEAD1 (0.42) | BMP1KAT8TEAD1YAP1MEN1 | |
| SCHEMBL22718047 | 0.87 | TEAD1 (0.42) | KAT8TEAD1YAP1MEN1KMT2A | |
| SCHEMBL24496062 | 0.87 | TEAD1 (0.37) | BMP1KAT8TEAD1YAP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |