Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.72 |
| ▸ | YAP1 | P46937 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648415 | 1.00 | TEAD1 (0.72) | TEAD1YAP1MEN1KMT2ATDP1 | |
| SCHEMBL22718301 | 0.87 | TEAD1 (0.76) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29438928 | 0.87 | TEAD1 (0.76) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL29438880 | 0.85 | TEAD1 (0.77) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL22718190 | 0.85 | TEAD1 (0.77) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL20767258 | 0.84 | TEAD1 (0.85) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL20779435 | 0.84 | TEAD1 (1.00) | TEAD1YAP1MEN1KMT2ATNNI3K | |
| SCHEMBL29438871 | 0.84 | TEAD1 (1.00) | TEAD1YAP1MEN1KMT2ATNNI3K | |
| SCHEMBL20766513 | 0.82 | TEAD1 (0.80) | TEAD1YAP1MEN1KMT2ATNNI3K | |
| SCHEMBL22718294 | 0.82 | TEAD1 (0.74) | TEAD1YAP1TNNI3KBRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120353-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |