Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 4/20 | 0.77 |
| ▸ | YAP1 | P46937 | 1/20 | 0.77 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 5/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22718190 | 1.00 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438838 | 0.91 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718188 | 0.91 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24788980 | 0.91 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL30135282 | 0.91 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718325 | 0.90 | TEAD1 (0.62) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL29438868 | 0.90 | TEAD1 (0.62) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL24501728 | 0.89 | TEAD1 (0.61) | TEAD1YAP1TNNI3KMAPTTLR2 | |
| SCHEMBL24501068 | 0.89 | TEAD1 (0.61) | TEAD1YAP1TNNI3KMAPTBRAF | |
| SCHEMBL22718301 | 0.88 | TEAD1 (0.76) | TEAD1YAP1TNNI3KMAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976194-A2 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |