SCHEMBL24496754

SCHEMBL24496754

O=C(NO)C1CCc2cc(C#CCOc3ccc(F)cc3)ccc2O1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 2/20 0.43
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
EPHX2 P34913 1/20 0.37
CYP4F2 P78329 5/20 0.36
CYP4A11 Q02928 5/20 0.36
MLNR O43193 1/20 0.36
ADRB2 P07550 1/20 0.36
ADRB1 P08588 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
CHRM1 P11229 1/20 0.36
DRD2 P14416 1/20 0.36
KCNE1 P15382 1/20 0.36
ADRA2B P18089 1/20 0.36
ADRA2C P18825 1/20 0.36
CNR1 P21554 1/20 0.36
SLC6A2 P23975 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29587242 1.00 EGLN1 (0.43) EGLN1HDAC3HDAC1HDAC2EPHX2
SCHEMBL24496755 0.89 EGLN1 (0.42) EGLN1HDAC3HDAC1HDAC2EPHX2
Lithium Ion SCHEMBL29586769 0.88 EGLN1 (0.41) EGLN1HDAC3HDAC1HDAC2EPHX2
SCHEMBL29586879 0.83 EGLN1 (0.39) EGLN1HDAC3HDAC1HDAC2EPHX2
SCHEMBL24496752 0.83 EGLN1 (0.39) EGLN1HDAC3HDAC1HDAC2EPHX2
SCHEMBL24496643 0.79 CYP4F2 (0.51) HDAC3HDAC1HDAC2CYP4F2CYP4A11
SCHEMBL29587347 0.79 CYP4F2 (0.51) HDAC3HDAC1HDAC2CYP4F2CYP4A11
SCHEMBL27091891 0.78 PPARG (0.48) HDAC3HDAC1HDAC2CYP4F2CYP4A11
SCHEMBL29587412 0.76 HDAC1 (0.59) HDAC3HDAC1HDAC2CYP4F2CYP4A11
SCHEMBL24496697 0.74 CYP4F2 (0.40) HDAC3HDAC1HDAC2CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022120048-A1 HDAC INHIBITORS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-06-09 WO disclosed