SCHEMBL29587347

SCHEMBL29587347

O=C(NO)C1CCc2cc(CCCOc3ccc(F)cc3)ccc2O1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 8/20 0.51
CYP4A11 Q02928 8/20 0.51
PPARG P37231 2/20 0.41
PPARA Q07869 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HTR2A P28223 2/20 0.40
MCHR1 Q99705 2/20 0.40
CHRM1 P11229 1/20 0.40
S1PR1 P21453 2/20 0.39
S1PR3 Q99500 2/20 0.39
FFAR4 Q5NUL3 1/20 0.38
DRD2 P14416 1/20 0.38
DRD1 P21728 1/20 0.38
DRD4 P21917 1/20 0.38
DRD5 P21918 1/20 0.38
DRD3 P35462 1/20 0.38
LTA4H P09960 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24496643 1.00 CYP4F2 (0.51) CYP4F2CYP4A11PPARGPPARAHDAC3
SCHEMBL24496642 0.89 CYP4F2 (0.51) CYP4F2CYP4A11PPARGPPARAHDAC3
SCHEMBL27091891 0.83 PPARG (0.48) CYP4F2CYP4A11PPARGPPARAHDAC3
SCHEMBL29587237 0.83 CYP4F2 (0.44) CYP4F2CYP4A11PPARGPPARAHDAC3
SCHEMBL29588068 0.79 MAOB (0.48) CYP4F2CYP4A11PPARGPPARA
SCHEMBL29587242 0.79 EGLN1 (0.43) CYP4F2CYP4A11HDAC3HDAC1HDAC2
SCHEMBL24496754 0.79 EGLN1 (0.43) CYP4F2CYP4A11HDAC3HDAC1HDAC2
SCHEMBL29587412 0.77 HDAC1 (0.59) CYP4F2CYP4A11HDAC3HDAC1HDAC2
SCHEMBL29588229 0.75 PPARG (0.51) CYP4F2CYP4A11PPARGPPARA
SCHEMBL24496740 0.74 CHRM5 (0.43) CYP4F2CYP4A11HTR2ACHRM1DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022120048-A1 HDAC INHIBITORS UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2022-06-09 WO disclosed