Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 10/20 | 0.77 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497387 | 1.00 | TEAD1 (0.77) | TEAD1TNNI3KMAPTBRAFYAP1 | |
| SCHEMBL24497388 | 1.00 | TEAD1 (0.77) | TEAD1TNNI3KMAPTBRAFYAP1 | |
| SCHEMBL24497414 | 0.89 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAFYAP1 | |
| SCHEMBL24497415 | 0.89 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAFYAP1 | |
| SCHEMBL29648418 | 0.88 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAFCCR6 | |
| SCHEMBL29648411 | 0.88 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAFCCR6 | |
| SCHEMBL24497430 | 0.88 | TEAD1 (0.61) | TEAD1TNNI3KMAPTBRAFCCR6 | |
| SCHEMBL22719850 | 0.87 | TEAD1 (1.00) | TEAD1TNNI3KYAP1 | |
| SCHEMBL22731733 | 0.87 | TEAD1 (1.00) | TEAD1TNNI3KYAP1 | |
| SCHEMBL22731670 | 0.87 | TEAD1 (1.00) | TEAD1TNNI3KYAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4281073-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2023-11-29 | — | — | EP | disclosed |
| EP-4255895-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022159986-A1 | COMBINATION OF A 3-(IMIDAZOL-4-YL)-4-(AMINO)-BENZENESULFONAMIDE TEAD INHIBITOR WITH AN EGFR INHIBITOR AND/OR MEK INHIBITOR FOR USE IN THE TREATMENT OF LUNG CANCER | Ikena Oncology, Inc. (US) | 2022-07-28 | — | — | WO | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |