Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 11/20 | 0.61 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29648411 | 1.00 | TEAD1 (0.61) | TEAD1TNNI3KMAPTCCR6BRAF | |
| SCHEMBL29648418 | 1.00 | TEAD1 (0.61) | TEAD1TNNI3KMAPTCCR6BRAF | |
| SCHEMBL29648430 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL24497320 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL29110484 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL24497408 | 0.89 | TEAD1 (0.74) | TEAD1TNNI3KMAPTBRAF | |
| SCHEMBL24497388 | 0.88 | TEAD1 (0.77) | TEAD1TNNI3KMAPTCCR6BRAF | |
| SCHEMBL24497387 | 0.88 | TEAD1 (0.77) | TEAD1TNNI3KMAPTCCR6BRAF | |
| SCHEMBL24497385 | 0.88 | TEAD1 (0.77) | TEAD1TNNI3KMAPTCCR6BRAF | |
| SCHEMBL24497323 | 0.78 | TEAD1 (0.58) | TEAD1TNNI3KMAPTBRAFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120354-A1 | TEAD INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |