SCHEMBL24497704

SCHEMBL24497704

Cc1ccc(F)cc1N(C)S(=O)(=O)C1CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 1/20 0.40
PSEN1 P49768 2/20 0.39
PSEN2 P49810 2/20 0.39
APH1B Q8WW43 2/20 0.39
NCSTN Q92542 2/20 0.39
APH1A Q96BI3 2/20 0.39
PSENEN Q9NZ42 2/20 0.39
ABL1 P00519 1/20 0.36
HSD17B1 P14061 2/20 0.34
HSD17B2 P37059 2/20 0.34
STS P08842 1/20 0.34
USP30 Q70CQ3 1/20 0.34
DDB1 Q16531 1/20 0.33
CRBN Q96SW2 1/20 0.33
KCNJ6 P48051 1/20 0.33
KCNJ5 P48544 1/20 0.33
KCNJ3 P48549 1/20 0.33
HTR2A P28223 3/20 0.33
HTR2C P28335 3/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24497515 0.84 LMNA (0.43) PIK3C3HTR2AHTR2CKMT2ACYP2C9
SCHEMBL24498003 0.83 PSEN1 (0.38) PIK3C3PSEN1PSEN2APH1BNCSTN
SCHEMBL24497520 0.82 PSEN1 (0.38) PIK3C3PSEN1PSEN2APH1BNCSTN
SCHEMBL24498513 0.81 TSHR (0.43) PIK3C3PSEN1PSEN2APH1BNCSTN
SCHEMBL24497541 0.80 PIK3C3 (0.37) PIK3C3HTR2AHTR2CCYP2C9
SCHEMBL24497545 0.79 CYP2C9 (0.45) PIK3C3KCNJ6KCNJ5KCNJ3KMT2A
SCHEMBL26118777 0.79 ATM (0.44) PIK3C3PSEN1PSEN2APH1BNCSTN
SCHEMBL26544596 0.79 PSEN1 (0.35) PIK3C3PSEN1PSEN2APH1BNCSTN
SCHEMBL2760306 0.78 PSEN1 (0.44) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL26513490 0.78 PIK3C3 (0.36) PIK3C3CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4257587-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shenzhen Chipscreen Biosciences Co., Ltd. (CN) 2023-10-11 EP disclosed
WO-2022117016-A1 HYDROXAMATE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 深圳微芯生物科技股份有限公司 2022-06-09 WO disclosed