Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24497790 | 0.79 | RXRA (0.43) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL24497734 | 0.78 | GRM5 (0.45) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL2291091 | 0.76 | PARP10 (0.55) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL20406250 | 0.75 | PDE10A (0.45) | RAB9ANPBWR1MCHR1 | |
| SCHEMBL625198 | 0.74 | FFAR1 (0.43) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL15845985 | 0.73 | NPC1 (0.40) | NPC1RAB9AKDM4ELMNAMAPT | |
| SCHEMBL16638704 | 0.73 | KDM4E (0.58) | MRGPRX4NPC1KDM4ELMNAMAPT | |
| SCHEMBL623669 | 0.73 | FFAR1 (0.43) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL18997950 | 0.71 | SMN1; SMN2 (0.53) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL9963342 | 0.70 | PDE3B (0.39) | NPC1RAB9AKDM4ELMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022119888-A1 | 3-HETEROARYL PYRROLIDINE AND PIPERIDINE OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-06-09 | — | — | WO | disclosed |