Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449941 | 1.00 | SCN4A (0.61) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL3330572 | 0.90 | SCN4A (0.59) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL3330577 | 0.90 | SCN4A (0.59) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL3331106 | 0.88 | SCN4A (0.58) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL3331101 | 0.88 | SCN4A (0.58) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL7423990 | 0.87 | KDM4E (0.61) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL12450708 | 0.82 | SCN4A (0.53) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL13523761 | 0.81 | NPC1 (0.53) | SCN4ANPC1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL2476806 | 0.80 | KDM4E (0.54) | SCN4ANPSR1SMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL2848716 | 0.78 | SMN1; SMN2 (0.60) | SCN4ANPC1LMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9120779-B2 | Inhibitors of HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2015-09-01 | — | — | US | disclosed |
| EP-2774927-A1 | Inhibitors of HCV NS5A | Presidio Pharmaceuticals, Inc. (US) | 2014-09-10 | — | — | EP | disclosed |
| US-20110237579-A1 | INHIBITORS OF HCV NS5A | PRESIDIO PHARMACEUTICALS, INC. (US) | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237579-A1 | INHIBITORS OF HCV NS5A | MAVS, HAVCR2, EIF2AK2 | SCN4A 3775/4885NPC1 368/4885LMNA 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.