Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 19/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694688 | 1.00 | POLQ (0.56) | POLQKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22717495 | 0.90 | POLQ (0.71) | POLQ | |
| SCHEMBL29574407 | 0.90 | POLQ (0.60) | POLQ | |
| SCHEMBL29575166 | 0.90 | POLQ (0.71) | POLQ | |
| SCHEMBL22717500 | 0.90 | POLQ (0.60) | POLQ | |
| SCHEMBL29108403 | 0.88 | POLQ (0.58) | POLQ | |
| SCHEMBL22718445 | 0.88 | POLQ (0.67) | POLQKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29574647 | 0.88 | POLQ (0.67) | POLQKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22717436 | 0.87 | POLQ (0.57) | POLQ | |
| SCHEMBL29574367 | 0.87 | POLQ (0.57) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |