Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 20/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29574407 | 1.00 | POLQ (0.60) | POLQ | |
| SCHEMBL22717495 | 0.92 | POLQ (0.71) | POLQ | |
| SCHEMBL29575166 | 0.92 | POLQ (0.71) | POLQ | |
| SCHEMBL24501199 | 0.90 | POLQ (0.56) | POLQ | |
| SCHEMBL29694688 | 0.90 | POLQ (0.56) | POLQ | |
| SCHEMBL22717436 | 0.90 | POLQ (0.57) | POLQ | |
| SCHEMBL29574367 | 0.90 | POLQ (0.57) | POLQ | |
| SCHEMBL22717790 | 0.88 | POLQ (0.62) | POLQ | |
| SCHEMBL29574377 | 0.88 | POLQ (0.62) | POLQ | |
| SCHEMBL24501180 | 0.87 | POLQ (0.72) | POLQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |