Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29695036 | 1.00 | PPARG (0.31) | PPARGPPARANPC1POLBRAB9A | |
| SCHEMBL29108325 | 0.84 | — | — | |
| SCHEMBL29695060 | 0.78 | — | — | |
| SCHEMBL29694894 | 0.76 | — | — | |
| SCHEMBL619744 | 0.76 | CCR9 (0.40) | PPARGPPARANPC1POLBRAB9A | |
| SCHEMBL3509480 | 0.76 | GBA1 (0.33) | — | |
| SCHEMBL29108305 | 0.75 | KDM4E (0.38) | POLB | |
| SCHEMBL24500398 | 0.75 | ALDH1A1 (0.34) | — | |
| SCHEMBL29108291 | 0.74 | — | — | |
| SCHEMBL2881587 | 0.73 | NPC1 (0.37) | PPARGPPARANPC1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |