Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29694798 | 1.00 | POLB (0.33) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL29108507 | 1.00 | POLB (0.33) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL29694773 | 1.00 | POLB (0.33) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL24501495 | 1.00 | POLB (0.33) | POLBGAAALDH1A1HPGDGFER | |
| SCHEMBL27293926 | 0.80 | POLB (0.35) | POLBGAA | |
| SCHEMBL24500874 | 0.80 | POLB (0.35) | POLBGAA | |
| SCHEMBL24500507 | 0.78 | POLB (0.33) | POLBGAA | |
| SCHEMBL24501440 | 0.77 | POLB (0.33) | POLBGAA | |
| SCHEMBL29694771 | 0.77 | POLB (0.33) | POLBGAA | |
| SCHEMBL20527910 | 0.75 | PPM1D (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023233295-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS AND USES THEREOF | IDEAYA BIOSCIENCES, INC. (US) | 2023-12-07 | — | — | WO | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |