Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | PDE8A | O60658 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | PDE8B | O95263 | 1/20 | 0.36 |
| ▸ | PDE6A | P16499 | 1/20 | 0.36 |
| ▸ | PDE6G | P18545 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE6B | P35913 | 1/20 | 0.36 |
| ▸ | PDE6C | P51160 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3420036 | 0.66 | PDE3B (0.36) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL557300 | 0.64 | GRIN2D (0.41) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL14034450 | 0.64 | IDO1 (0.32) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL232091 | 0.63 | PDE4A (0.47) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL12638629 | 0.63 | PARP1 (0.41) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL8148622 | 0.63 | PDE4A (0.32) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL6713740 | 0.63 | ALDH1A1 (0.45) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL232090 | 0.63 | PNP (0.37) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL12241751 | 0.63 | PDE3B (0.44) | PDE3BPDE3APDE2APDE6DPDE8A | |
| SCHEMBL4613160 | 0.63 | PARP1 (0.35) | PDE3BPDE3APDE2APDE6DPDE8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114184-A1 | AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-09-22 | — | — | WO | disclosed |