Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLQ | O75417 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30640253 | 1.00 | GRM7 (0.47) | GRM7MAPTPOLQMEN1KMT2A | |
| SCHEMBL24500450 | 0.93 | GRM7 (0.48) | GRM7MAPTPOLQMEN1KMT2A | |
| SCHEMBL24500447 | 0.91 | DPP4 (0.48) | GRM7MAPTPOLQ | |
| SCHEMBL29694825 | 0.91 | DPP4 (0.48) | GRM7MAPTPOLQ | |
| SCHEMBL29575480 | 0.90 | POLQ (0.48) | POLQ | |
| SCHEMBL22717429 | 0.90 | POLQ (0.48) | POLQ | |
| SCHEMBL29694637 | 0.90 | POLQ (0.48) | POLQ | |
| SCHEMBL22717310 | 0.87 | POLQ (0.46) | POLQ | |
| SCHEMBL29694862 | 0.85 | GRM7 (0.43) | GRM7MAPTPOLQMEN1KMT2A | |
| SCHEMBL29108210 | 0.85 | GRM7 (0.43) | GRM7MAPTPOLQMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083271-A | Substituted thiadiazolyl derivatives as DNA polymerase theta inhibitors | 伊迪亚生物科学有限公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2022118210-A1 | SUBSTITUTED THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2022-06-09 | — | — | WO | disclosed |