Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22717429 | 1.00 | POLQ (0.48) | POLQGPBAR1HTR5ALRRK2KDM4E | |
| SCHEMBL29694637 | 1.00 | POLQ (0.48) | POLQGPBAR1HTR5ALRRK2KDM4E | |
| SCHEMBL24770167 | 0.91 | POLQ (0.43) | POLQGPBAR1HTR5ALRRK2KDM4E | |
| SCHEMBL30017759 | 0.91 | POLQ (0.43) | POLQGPBAR1HTR5ALRRK2KDM4E | |
| SCHEMBL24501582 | 0.90 | GRM7 (0.47) | POLQ | |
| SCHEMBL30640253 | 0.90 | GRM7 (0.47) | POLQ | |
| SCHEMBL22717310 | 0.90 | POLQ (0.46) | POLQGPBAR1HTR5ALRRK2CTSA | |
| SCHEMBL25306864 | 0.85 | POLQ (0.63) | POLQGPBAR1KDM4ECTSAABL1 | |
| SCHEMBL30526637 | 0.85 | POLQ (0.63) | POLQGPBAR1KDM4ECTSAABL1 | |
| SCHEMBL29198977 | 0.84 | POLQ (0.49) | POLQGPBAR1HTR5ALRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |