Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.61 |
| ▸ | YAP1 | P46937 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 2/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24501068 | 0.90 | TEAD1 (0.61) | TEAD1YAP1KDM4EGAATLR2 | |
| SCHEMBL22718190 | 0.89 | TEAD1 (0.77) | TEAD1YAP1TLR2TLR1TSHR | |
| SCHEMBL29438880 | 0.89 | TEAD1 (0.77) | TEAD1YAP1TLR2TLR1TSHR | |
| SCHEMBL24501692 | 0.88 | TEAD1 (0.59) | TEAD1YAP1KDM4EGAATLR2 | |
| SCHEMBL22718325 | 0.87 | TEAD1 (0.62) | TEAD1YAP1KDM4ETLR2TLR1 | |
| SCHEMBL29438868 | 0.87 | TEAD1 (0.62) | TEAD1YAP1KDM4ETLR2TLR1 | |
| SCHEMBL22718322 | 0.86 | TEAD1 (0.58) | TEAD1YAP1KDM4EGAATLR2 | |
| SCHEMBL24497427 | 0.84 | TEAD1 (0.50) | TEAD1YAP1TSHRL3MBTL1MAPK10 | |
| SCHEMBL29648357 | 0.84 | TEAD1 (0.50) | TEAD1YAP1TSHRL3MBTL1MAPK10 | |
| SCHEMBL22843430 | 0.84 | TEAD1 (0.54) | TEAD1YAP1KDM4EGAATLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| WO-2022120355-A1 | TEAD DEGRADERS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |