Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethoprim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | SLC22A1 | O15245 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethoprim SCHEMBL29462189 | 1.00 | DHFR (1.00) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL2637561 | 1.00 | DHFR (1.00) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL29002279 | 0.99 | DHFR (0.97) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL27453244 | 0.99 | DHFR (0.97) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL1236697 | 0.99 | DHFR (0.97) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL5702287 | 0.99 | DHFR (0.97) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL547988 | 0.99 | DHFR (0.97) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL21722101 | 0.97 | DHFR (0.94) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL29236486 | 0.97 | DHFR (0.94) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL29225821 | 0.97 | DHFR (0.94) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 62149 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747395-A1 | A KIT FOR IDENTIFYING BACTERIA AND DETERMINING ANTIBIOTIC SENSITIVITY | Diagopreutic Private Limited (IN) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026104587-A1 | CYCLIC BORONIC ACID ESTERS USEFUL AS ADJUVANTS IN THE TREATMENT OF BACTERIAL INFECTIONS | ADJUTEC PHARMA AS (NO) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4743573-A1 | DROPLET-BASED SINGLE-CELL JOINT PROFILING OF CHROMATIN TARGETS AND TRANSCRIPTOME | Xie, Yang (US) | 2026-05-20 | — | — | EP | claimed |
| EP-4743153-A1 | MEDICAL SYSTEMS FOR TREATING CONDITIONS AND DISEASES OF THE PATIENT'S BODY CAVITIES | UTT Urine Topical Treatment Ltd (IL) | 2026-05-20 | — | — | EP | claimed |
| EP-4007582-B1 | ANTIBIOTICS IN COMBINATION WITH PHOTODYNAMIC THERAPY FOR USE IN A METHOD OF ENHANCING THE ANTIMICROBIAL ACTION OF SYSTEMICALLY ADMINISTERED ANTIBIOTICS | KOITE HEALTH OY (FI) | 2026-05-20 | — | — | EP | claimed |
| CN-122038211-A | Hafnia alvei strain and application thereof | 江西省农业科学院畜牧兽医研究所 | 2026-05-15 | — | — | CN | claimed |
| WO-2026102435-A1 | METHODS OF NUCLEIC ACID PROCESSING AND SYNTHESIS | UNIVERSITY OF MASSACHUSETTS (US) | 2026-05-15 | — | — | WO | claimed |
| CN-122032730-A | Mineral separation method for recovering fine-particle-grade cassiterite from tin-containing tailings | 长沙矿山研究院有限责任公司 | 2026-05-15 | — | — | CN | claimed |
| US-4190495-A | GROWING MICROORGANISM CONTAINING RECOMBINATE DNA-CONTAINING CLONING VECTOR FOR REPLICATION OF VECTOR | RESEARCH CORPORATION (US) | 1980-02-26 | — | — | US | claimed |
| EP-0007591-A1 | Stable medicinal solution on the basis of 2,6-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine(trimethoprim) and a sulphonamide, process for preparing and using it | CIBA-GEIGY AG (CH) | 1980-02-06 | — | — | EP | claimed |
| EP-0005891-A1 | Process for the preparation of a unit for the determination of residues of antibiotics and sulphas in biological liquids and such units. | GIST-BROCADES N.V. (NL) | 1979-12-12 | — | — | EP | claimed |
| EP-0001796-A1 | Anti-malaria drug | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-16 | — | — | EP | claimed |
| US-4133879-A | Process for producing stable solutions of a sulphonamide and a potentiator | AKTIESELSKABET ROSCO (DK) | 1979-01-09 | — | — | US | claimed |
| US-4125721-A | Process for the production of 2,4-diamino-5-(3',4',5'-trimethoxybenzyl)-pyrimidine | LUDWIG HEUMANN & CO. GMBH (DE) | 1978-11-14 | — | — | US | claimed |
| US-4125610-A | PHOSPHANILIC ACID AND TRIMETHOPRIM | BRISTOL-MYERS COMPANY (US) | 1978-11-14 | — | — | US | claimed |
| US-4016267-A | BACTERICIDES | HOFFMANN-LA ROCHE INC. (US) | 1977-04-05 | — | — | US | claimed |
| US-3996356-A | ANTIBACTERIAL | HOFFMANN-LA ROCHE INC. (US) | 1976-12-07 | — | — | US | claimed |
| US-3985873-A | OPHTHALMIC ANTIBACTERIAL SOLUTION | BURROUGHS WELLCOME CO. (US) | 1976-10-12 | — | — | US | claimed |