Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050306 | 0.77 | POLB (0.55) | POLBGAATSHRF2RTHRB | |
| SCHEMBL14612492 | 0.74 | CYP3A4 (0.45) | GAACYP3A4TSHRKDM4EALDH1A1 | |
| SCHEMBL8259539 | 0.73 | GAA (0.44) | POLBGAACYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL16956097 | 0.73 | CYP3A4 (0.48) | POLBGAACYP3A4KDM4EALDH1A1 | |
| SCHEMBL23815099 | 0.71 | ESR1 (0.55) | POLBGAACYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL16960526 | 0.71 | CYP3A4 (0.42) | POLBGAACYP3A4KDM4EALDH1A1 | |
| SCHEMBL13889273 | 0.70 | HTT (0.50) | POLBGAATSHRKDM4EALDH1A1 | |
| SCHEMBL23128682 | 0.70 | CYP3A4 (0.45) | GAACYP3A4KDM4EALDH1A1 | |
| SCHEMBL3922668 | 0.70 | ALDH1A1 (0.47) | POLBGAACYP3A4TSHRSMN1; SMN2 | |
| SCHEMBL25765618 | 0.69 | ALDH1A1 (0.46) | POLBGAATSHRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288921-B1 | POLYCYCLIC INDOLINE AND INDOLENINE COMPOUNDS | UNIV COLORADO REGENTS (US) | 2022-06-15 | — | — | EP | disclosed |