Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | CDK4 | P11802 | 1/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30086450 | 0.83 | JAK2 (0.51) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL23906917 | 0.83 | JAK2 (0.51) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL3547318 | 0.80 | CDK2 (0.76) | JAK2JAK3CDK4CDK6MAPK9 | |
| SCHEMBL2551874 | 0.79 | CSF1R (0.56) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL27387202 | 0.77 | JAK2 (0.74) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL6116123 | 0.76 | NPY2R (0.51) | JAK2JAK3SYKCSF1RCDK4 | |
| SCHEMBL24507554 | 0.76 | IGF1R (0.47) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL29716018 | 0.76 | IGF1R (0.47) | JAK2JAK3JAK1TYK2SYK | |
| SCHEMBL4378723 | 0.75 | JAK2 (0.76) | JAK2JAK3JAK1TYK2EGFR | |
| SCHEMBL4384852 | 0.75 | JAK2 (0.66) | JAK2JAK3JAK1TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022126133-A1 | ALK-5 INHIBITORS AND USES THEREOF | SUMITOMO PHARMA ONCOLOGY,INC. (US) | 2022-06-16 | — | — | WO | disclosed |