Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.56 |
| ▸ | CDK4 | P11802 | 4/20 | 0.56 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK9 | P50750 | 1/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15790797 | 0.88 | SYK (0.51) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL19527697 | 0.85 | SYK (0.48) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL4039797 | 0.80 | SYK (0.49) | SYKJAK3JAK2JAK1TYK2 | |
| SCHEMBL24507533 | 0.79 | JAK2 (0.57) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL3955783 | 0.77 | AXL (0.59) | CSF1RMAPK9SYKJAK3JAK2 | |
| SCHEMBL3553588 | 0.77 | CDK2 (0.81) | CSF1RCDK4CDK6CDK2KCNH2 | |
| SCHEMBL24385958 | 0.77 | CDK4 (0.51) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL19527758 | 0.76 | NPC1 (0.46) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL22171205 | 0.75 | CCND1 (0.63) | CSF1RCDK4CDK6MAPK9MAPK10 | |
| SCHEMBL28447910 | 0.75 | JAK3 (0.65) | CSF1RCDK4CDK6MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558474-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | claimed |
| WO-2011130390-A1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2011-10-20 | — | — | WO | claimed |