Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 5/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PGK2 | P07205 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20402885 | 0.84 | ADRB1 (0.49) | ADRB1P2RX7IDH1NOTUMIDH2 | |
| SCHEMBL19540540 | 0.84 | ADRB1 (0.57) | ADRB1P2RX7PNMTIDH1NOTUM | |
| SCHEMBL27186114 | 0.81 | ADRB1 (0.50) | ADRB1P2RX7IDH1IDH2IRAK4 | |
| SCHEMBL13184023 | 0.81 | ADRB1 (0.58) | ADRB1P2RX7IDH1NOTUMIDH2 | |
| SCHEMBL27186121 | 0.81 | ADRB1 (0.50) | ADRB1P2RX7IDH1IDH2IRAK4 | |
| SCHEMBL8124122 | 0.80 | ADRB1 (0.61) | ADRB1P2RX7PNMTIDH1NOTUM | |
| SCHEMBL18793684 | 0.80 | ADRB1 (0.50) | ADRB1P2RX7PNMTIDH1NOTUM | |
| SCHEMBL28151259 | 0.78 | ADRB1 (0.50) | ADRB1P2RX7IDH1NOTUMPGK1 | |
| SCHEMBL30676298 | 0.78 | ADRB1 (0.51) | ADRB1P2RX7PNMTIDH1NOTUM | |
| SCHEMBL17574510 | 0.77 | ADRB1 (0.50) | ADRB1P2RX7IDH1NOTUMIDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11779578-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11779578-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | ADRB1 4186/4885P2RX7 1103/4885PNMT 4198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.