Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22848919 | 0.84 | KDM4E (0.44) | ACHEDRD2KDM4EMEN1KMT2A | |
| SCHEMBL25477805 | 0.84 | SMN1; SMN2 (0.44) | DRD2DRD3TP53SMN1; SMN2KDM4E | |
| SCHEMBL25913732 | 0.84 | SMN1; SMN2 (0.44) | DRD2DRD3TP53SMN1; SMN2KDM4E | |
| SCHEMBL10109056 | 0.83 | MEN1 (0.48) | ACHEDRD2DRD3TP53SMN1; SMN2 | |
| SCHEMBL23568038 | 0.82 | MEN1 (0.46) | ACHEDRD2TP53SMN1; SMN2KDM4E | |
| SCHEMBL25467315 | 0.81 | HRH3 (0.39) | DRD2DRD3TP53SMN1; SMN2KDM4E | |
| SCHEMBL25123160 | 0.81 | MEN1 (0.49) | ACHEDRD2TP53SMN1; SMN2KDM4E | |
| SCHEMBL23945511 | 0.81 | DRD4 (0.46) | DRD2KDM4EMEN1KMT2ATDP1 | |
| SCHEMBL25477724 | 0.79 | HRH3 (0.38) | DRD2DRD3TP53SMN1; SMN2KDM4E | |
| SCHEMBL24334518 | 0.79 | ACHE (0.42) | ACHETP53SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |