Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.34 |
| ▸ | BTK | Q06187 | 9/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 7/20 | 0.33 |
| ▸ | QDPR | P09417 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26157132 | 0.85 | SLC18A3 (0.36) | JAK3BTKKDM4EALDH1A1SLC18A3 | |
| SCHEMBL23602804 | 0.79 | KDM4E (0.35) | JAK3BTKKDM4EALDH1A1SLC18A3 | |
| SCHEMBL26157130 | 0.79 | HRH3 (0.39) | JAK3BTKKDM4ELCKCYP2C19 | |
| SCHEMBL25111181 | 0.78 | JAK3 (0.34) | JAK3BTKSLC18A3LCKEGFR | |
| SCHEMBL25109073 | 0.78 | JAK3 (0.34) | JAK3BTKSLC18A3LCKEGFR | |
| SCHEMBL22794061 | 0.74 | IRAK4 (0.41) | JAK3BTKKDM4EALDH1A1SLC18A3 | |
| SCHEMBL25604617 | 0.71 | JAK3 (0.35) | JAK3BTKKDM4EALDH1A1SLC18A3 | |
| SCHEMBL25604629 | 0.71 | JAK3 (0.35) | JAK3BTKKDM4EALDH1A1SLC18A3 | |
| SCHEMBL25604813 | 0.71 | CHRM4 (0.39) | JAK3BTKSLC18A3CHRM2CHRM1 | |
| SCHEMBL25604873 | 0.71 | CHRM4 (0.39) | JAK3BTKCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125800-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |