Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 5/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26345034 | 0.92 | ACACB (0.40) | APPHRH3FFAR1FFAR4GPER1 | |
| SCHEMBL29416754 | 0.92 | ACACB (0.40) | APPHRH3FFAR1FFAR4GPER1 | |
| SCHEMBL29416716 | 0.92 | ACACB (0.40) | APPHRH3FFAR1FFAR4GPER1 | |
| SCHEMBL28703678 | 0.92 | ACACB (0.40) | APPHRH3FFAR1FFAR4GPER1 | |
| SCHEMBL26345001 | 0.92 | ACACB (0.40) | APPHRH3FFAR1FFAR4GPER1 | |
| SCHEMBL6567753 | 0.86 | PTGS1 (0.48) | APPFFAR1PTGS1PTGS2FFAR4 | |
| SCHEMBL15785548 | 0.81 | APP (0.45) | APPMAPK14HRH3FFAR1PTGS1 | |
| SCHEMBL29416715 | 0.77 | APP (0.43) | APPMAPK14HRH3FFAR1PTGS1 | |
| SCHEMBL28691522 | 0.77 | APP (0.43) | APPMAPK14HRH3FFAR1PTGS1 | |
| SCHEMBL15782898 | 0.77 | SYK (0.44) | APPMAPK14HRH3FFAR1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114149423-B | Tetrahydropyridopyrimidinedione derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-12-12 | — | — | CN | disclosed |
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
| CN-114149423-A | Tetrahydropyridopyrimidine diketone derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | APP 3995/4885MAPK14 1784/4885HRH3 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.