Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18739821 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL3211023 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL31396028 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL3211034 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL12292157 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL17790447 | 1.00 | ALDH1A1 (0.43) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL30288738 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL30288799 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL30288660 | 0.98 | ALDH1A1 (0.42) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB | |
| SCHEMBL5732376 | 0.86 | ALDH1A1 (0.44) | ALDH1A1CYP2C19KDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023237512-A1 | COMBINATIONS OF RXFP1 MODULATORS AND SGLT2 INHIBITORS | ASTRAZENECA AB (SE) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023237510-A1 | SOLID FORMS OF RXFP1 MODULATORS | ASTRAZENECA AB (SE) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023237511-A1 | RXFP1 MODULATORS FOR TREATING RESISTANT HYPERTENSION OR HEART FAILURE WITH PULMONARY HYPERTENSION | ASTRAZENECA AB (SE) | 2023-12-14 | — | — | WO | disclosed |
| US-20230348363-A1 | COMPOUNDS AND THEIR USE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2023-11-02 | — | — | US | disclosed |
| US-11667602-B2 | Compounds and their use | ASTRAZENECA AB (SE) | 2023-06-06 | — | — | US | disclosed |
| US-11667602-B2 | Compounds and their use | ASTRAZENECA AB (SE) | 2023-06-06 | — | — | US | disclosed |
| WO-2022122773-A1 | 4-(2-FLUORO-4-METHOXY-5-3-(((1-METHYLCYCLOBUTYL)METHYL)CARBAMOYL)BICYCLO[2.2.1]HEPTAN-2-YL)CARBAMOYL)PHENOXY)-1-METHYLCYCLOHEXANE-1-CARBOXYLIC ACID DERIVATIVES AND SIMILAR COMPOUNDS AS RXFP1 MODULATORS FOR THE TREATMENT OF HEART FAILURE | ASTRAZENECA AB (SE) | 2022-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667602-B2 | Compounds and their use | RXFP1, RXFP3, RXFP2 | ALDH1A1 1531/4885CYP2C19 3076/4885KDM4E 2832/4885 |
| US-20230348363-A1 | COMPOUNDS AND THEIR USE | RXFP1, RXFP3, RXFP2 | ALDH1A1 1531/4885CYP2C19 3076/4885KDM4E 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.