Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 7/20 | 0.40 |
| ▸ | CDK8 | P49336 | 7/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 12/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15360083 | 0.79 | MKNK1 (0.46) | HRH4 | |
| SCHEMBL1318963 | 0.79 | TNNI3K (0.36) | CCNCCDK8PIK3C3 | |
| SCHEMBL23073683 | 0.70 | TRPA1 (0.55) | PIK3C3 | |
| SCHEMBL1317272 | 0.69 | ADORA1 (0.34) | — | |
| SCHEMBL4555915 | 0.68 | PLD1 (0.41) | PIK3C3 | |
| SCHEMBL15360082 | 0.68 | HRH4 (0.50) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL16622459 | 0.68 | HRH4 (0.64) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL9891829 | 0.68 | HRH4 (0.37) | CCNCCDK8HRH4HRH3 | |
| SCHEMBL28137564 | 0.67 | PDE10A (0.40) | PIK3C3 | |
| SCHEMBL13619336 | 0.67 | HRH4 (0.66) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |