Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680736 | 0.81 | RAB9A (0.40) | TSHRMAPK1HSD17B10TDP1KMT2A | |
| SCHEMBL14341115 | 0.80 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL13255050 | 0.79 | TSHR (0.36) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL20351153 | 0.79 | TSHR (0.41) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL13963714 | 0.77 | TSHR (0.48) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL20646464 | 0.74 | TSHR (0.38) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL20404611 | 0.74 | TSHR (0.38) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL11999050 | 0.70 | — | — | |
| SCHEMBL17696865 | 0.69 | TSHR (0.40) | TSHRMAPK1HSD17B10TDP1THRB | |
| SCHEMBL24315427 | 0.69 | TSHR (0.34) | TSHRMAPK1HSD17B10TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052501-B1 | BICYCLIC ALKYNE DERIVATIVES AND USES THEREOF | AGENCY SCIENCE TECH & RES (SG) | 2022-06-22 | — | — | EP | disclosed |