Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2449348 | 0.72 | CCR8 (0.51) | KMT2AALDH1A1MEN1DRD2SIGMAR1 | |
| SCHEMBL14252518 | 0.70 | ADRB1 (0.53) | ADRB1KMT2AALDH1A1MEN1HTR6 | |
| SCHEMBL4144093 | 0.69 | HSD17B10 (0.36) | — | |
| SCHEMBL6618744 | 0.68 | KMT2A (0.49) | KMT2AALDH1A1MEN1CYP2D6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL31537337 | 0.68 | HSD17B10 (0.35) | — | |
| SCHEMBL17128982 | 0.65 | MEN1 (0.45) | KMT2AALDH1A1MEN1 | |
| SCHEMBL26116014 | 0.65 | GAA (0.38) | KMT2AALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL2452166 | 0.64 | SMN1; SMN2 (0.36) | CYP3A4 | |
| SCHEMBL12847145 | 0.64 | MEN1 (0.39) | ADRB1KMT2AALDH1A1MEN1HTR6 | |
| SCHEMBL27629672 | 0.64 | CA1 (0.41) | ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364982-A1 | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof | ONO Pharmaceutical Co., Ltd. (JP) | 2011-09-14 | — | — | EP | disclosed |