Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 20/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12313683 | 0.95 | DGAT1 (0.84) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2395115 | 0.93 | DGAT1 (0.98) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2391281 | 0.92 | DGAT1 (1.00) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL2393129 | 0.92 | DGAT1 (0.93) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL13356357 | 0.92 | DGAT1 (0.84) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313667 | 0.91 | DGAT1 (0.81) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313835 | 0.91 | DGAT1 (0.81) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313827 | 0.91 | DGAT1 (0.78) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL12313706 | 0.91 | DGAT1 (0.78) | DGAT1CYP3A4CYP2C9 | |
| SCHEMBL13356343 | 0.91 | DGAT1 (0.83) | DGAT1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716312-B2 | Inhibitors of diacylglycerol acyltransferase | MERCK SHARP & DOHME CORPORATION (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2367598-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2011-09-28 | — | — | EP | disclosed |
| WO-2010059602-A2 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-05-27 | — | — | WO | disclosed |