Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 20/20 | 0.67 |
| ▸ | MST1R | Q04912 | 4/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | FECH | P22830 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2446221 | 0.82 | MET (0.77) | METMST1R | |
| SCHEMBL2444026 | 0.81 | MET (0.74) | METMST1R | |
| SCHEMBL2447742 | 0.80 | MET (0.67) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2452277 | 0.80 | MET (0.60) | METMST1R | |
| SCHEMBL2325443 | 0.80 | MET (0.74) | METMST1R | |
| SCHEMBL2447025 | 0.80 | MET (0.77) | METMST1R | |
| SCHEMBL2447032 | 0.79 | MET (0.72) | METMST1R | |
| SCHEMBL2447085 | 0.78 | MET (0.82) | METMST1R | |
| SCHEMBL14305341 | 0.78 | MET (0.71) | METMST1RCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL401277 | 0.78 | MET (0.83) | METMST1RCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896421-B1 | BENZOCYCLOHEPTAPYRIDINES AS INHIBITORS OF THE RECEPTOR TYROSINE KINASE MET | MERCK SHARP & DOHME (US) | 2011-09-14 | — | — | EP | claimed |