Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ARAF | P10398 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | FECH | P22830 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24523141 | 0.85 | MAP2K4 (0.55) | MAP2K4CYP2C9BRAFCYP2C19RIPK2 | |
| SCHEMBL29725811 | 0.83 | MAP2K4 (0.73) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL20408848 | 0.83 | MAP2K4 (0.73) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL20408718 | 0.83 | MAP2K4 (0.53) | MAP2K4CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL27101338 | 0.82 | CYP2C9 (0.73) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL20400057 | 0.80 | MAP2K4 (0.70) | MAP2K4CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL29898540 | 0.77 | CYP2C9 (0.58) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL21624564 | 0.77 | CYP2C9 (0.58) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL20408840 | 0.75 | BRAF (0.56) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 | |
| SCHEMBL29898678 | 0.74 | MAP2K4 (0.66) | MAP2K4CYP2C9CYP3A4BRAFCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571200-B1 | PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2022-06-22 | — | — | EP | disclosed |