SCHEMBL2452373

SCHEMBL2452373

CC(C)(C)C1CC(Oc2ccn(-c3ccc(C#N)cc3F)c(=O)c2)CCN1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR6 P46095 14/20 0.41
GPR119 Q8TDV5 6/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2452074 0.85 GPR119 (0.45) GPR6GPR119
SCHEMBL2458138 0.84 GPR119 (0.41) GPR119
SCHEMBL2333369 0.80 GPR119 (0.59) GPR6GPR119
SCHEMBL4101596 0.79 GPR119 (0.53) GPR119
SCHEMBL2333880 0.77 GPR119 (0.59) GPR6GPR119
SCHEMBL2452405 0.77 GPR119 (0.50) GPR119
SCHEMBL12333986 0.76 GPR119 (0.44) GPR6GPR119
SCHEMBL2452825 0.76 GPR119 (0.64) GPR119
SCHEMBL8511976 0.75 RET (0.35) GPR6
SCHEMBL2450627 0.74 GPR119 (0.51) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2170864-B1 PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2011-09-14 EP claimed