SCHEMBL24523809

SCHEMBL24523809

N#Cc1ccc2c3cc(-c4cccc5ccc6ccccc6c45)cc4c5ccc(C#N)cc5n(c2c1)c34

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
ENPP3 O14638 1/20 0.39
PDPK1 O15530 1/20 0.36
KDM4E B2RXH2 3/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
MAPT P10636 2/20 0.35
HTT P42858 2/20 0.35
LMNA P02545 1/20 0.35
STK10 O94804 1/20 0.33
SLK Q9H2G2 1/20 0.33
PIM1 P11309 2/20 0.33
CYP19A1 P11511 1/20 0.33
MCL1 Q07820 1/20 0.33
CDC7 O00311 1/20 0.32
CDK2 P24941 1/20 0.32
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24523829 0.90 CA1 (0.43) CA1CA2ENPP3PDPK1KDM4E
SCHEMBL24523808 0.90 CA1 (0.42) CA1CA2ENPP3PDPK1STK10
SCHEMBL24523830 0.88 ENPP3 (0.37) CA1CA2ENPP3CYP19A1
SCHEMBL24523716 0.84 ENPP3 (0.35) CA1CA2ENPP3KDM4EALDH1A1
SCHEMBL24523810 0.81 PDPK1 (0.47) CA1CA2ENPP3PDPK1KDM4E
SCHEMBL24523714 0.81 ENPP3 (0.33) ENPP3
SCHEMBL24523765 0.81 PTGDR2 (0.40) ENPP3CYP19A1MEN1KMT2A
SCHEMBL24523822 0.80 CA1 (0.41) CA1CA2ENPP3PDPK1CYP19A1
SCHEMBL24523821 0.79 CYP11B1 (0.42) CA1CA2ENPP3PDPK1MEN1
SCHEMBL24523831 0.77 ENPP3 (0.37) CA1CA2ENPP3CDC7CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022129116-A1 INDOLO[3.2.1-JK]CARBAZOLE-6-CARBONITRILE DERIVATIVES AS BLUE FLUORESCENT EMITTERS FOR USE IN OLEDS MERCK PATENT GMBH (DE) 2022-06-23 WO disclosed