Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24525033 | 1.00 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL24337770 | 1.00 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL227684 | 0.88 | TSHR (0.48) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL7332107 | 0.82 | TRPA1 (0.47) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL7332119 | 0.82 | TRPA1 (0.47) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL11563306 | 0.81 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL6379469 | 0.81 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL28376888 | 0.81 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL11197240 | 0.81 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 | |
| SCHEMBL28576014 | 0.81 | SLC1A3 (0.42) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-4076667-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |