Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29654654 | 0.88 | CFTR (0.50) | ABL1SLC1A3SLC1A2SLC1A1MAPT | |
| SCHEMBL24525035 | 0.88 | CFTR (0.50) | ABL1SLC1A3SLC1A2SLC1A1MAPT | |
| SCHEMBL29654580 | 0.84 | CFTR (0.55) | ABL1SLC1A3SLC1A2SLC1A1SCN9A | |
| SCHEMBL24525042 | 0.84 | CFTR (0.55) | ABL1SLC1A3SLC1A2SLC1A1SCN9A | |
| SCHEMBL23557088 | 0.83 | SLC6A4 (0.56) | ABL1MAPTCASP3SENP7KDM4E | |
| SCHEMBL29654682 | 0.83 | ABL1 (0.63) | ABL1MAPTCASP3SENP7MEN1 | |
| SCHEMBL24524941 | 0.83 | ABL1 (0.63) | ABL1MAPTCASP3SENP7MEN1 | |
| SCHEMBL23557174 | 0.82 | ABL1 (0.44) | ABL1MAPTCASP3SENP7MEN1 | |
| SCHEMBL25486723 | 0.82 | ABL1 (0.44) | ABL1SLC1A3SLC1A2SLC1A1SCN9A | |
| SCHEMBL15921270 | 0.78 | MAPT (0.53) | SLC1A3SLC1A2SLC1A1MAPTCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |