Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 6/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.46 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24525042 | 1.00 | CFTR (0.55) | CFTRSLC1A3SLC1A2SLC1A1ABL1 | |
| SCHEMBL29654654 | 0.84 | CFTR (0.50) | CFTRSLC1A3SLC1A2SLC1A1ABL1 | |
| SCHEMBL24525040 | 0.84 | ABL1 (0.49) | CFTRSLC1A3SLC1A2SLC1A1ABL1 | |
| SCHEMBL24525035 | 0.84 | CFTR (0.50) | CFTRSLC1A3SLC1A2SLC1A1ABL1 | |
| SCHEMBL29476183 | 0.84 | CFTR (0.60) | CFTRABL1MAPTCASP3SENP7 | |
| SCHEMBL23540424 | 0.84 | CFTR (0.60) | CFTRABL1MAPTCASP3SENP7 | |
| SCHEMBL29476232 | 0.83 | CFTR (0.52) | CFTRABL1MAPTNOTUMPDGFRB | |
| SCHEMBL23540410 | 0.83 | CFTR (0.52) | CFTRABL1MAPTNOTUMPDGFRB | |
| SCHEMBL24524870 | 0.83 | ABL1 (0.44) | CFTRSLC1A3SLC1A2SLC1A1ABL1 | |
| SCHEMBL29654471 | 0.83 | ABL1 (0.44) | CFTRSLC1A3SLC1A2SLC1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |