Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.32 |
| ▸ | AGER | Q15109 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29681239 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1ALOX15ADORA2AENPP2 | |
| SCHEMBL24528662 | 0.90 | ALDH1A1 (0.36) | KDM4EALDH1A1ALOX15ADORA2ASMN1; SMN2 | |
| SCHEMBL29681009 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1ALOX15CXCR1NPC1 | |
| SCHEMBL24528587 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1ALOX15CXCR1NPC1 | |
| SCHEMBL24528685 | 0.82 | KDM4E (0.40) | KDM4EALDH1A1ALOX15CXCR1AGER | |
| SCHEMBL29681200 | 0.82 | KDM4E (0.40) | KDM4EALDH1A1ALOX15CXCR1AGER | |
| SCHEMBL24528664 | 0.81 | ADORA2A (0.34) | KDM4EALDH1A1ADORA2A | |
| SCHEMBL29680554 | 0.78 | RAD52 (0.37) | KDM4EALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL24528648 | 0.78 | RAD52 (0.37) | KDM4EALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL29680577 | 0.77 | AKT1 (0.47) | KDM4EALDH1A1ADORA2AHRH3RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022129376-A1 | 6-6 OR 5-6 FUSED BICYCLIC COMPOUNDS COMPRISING A PYRI(MI)DINE RING USEFUL IN THE|TREATMENT OF INFECTIOUS DISEASES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-06-23 | — | — | WO | disclosed |